Proton pump initiators (PPIs) are drugs that are primarily used for profound and prolonged reduction of stomach acid levels in individuals suffering from hyperacidity, gastroesophageal reflux disease, and ulcers. PPIs possess a unique mechanism of action as they are given in an inactive form that is lipophilic and readily crosses cell membranes into intracellular compartments such as the parietal cell canaliculus with an acidic environment, then the inactive drug is rearranged after protonation into its active form in an acidic environment, which irreversibly blocks the gastric proton pump of
Source: https://www.stratviewresearch.com/1660/proton-pump-inhibitors-(PPIs)-market.html
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